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Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
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Lipidomics informatics for life-science.

D Schwudke1, A Shevchenko2, N Hoffmann3

  • 1Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.

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|August 21, 2017
PubMed
Summary
This summary is machine-generated.

Lipidomics informatics infrastructure is being standardized to improve access to bioinformatics tools for lipidome analysis. This initiative supports research into lipid metabolic alterations and related medical challenges.

Keywords:
BioinformaticsLIFSLipidCreatorLipidXplorerLipidomicsLux-ScoreSkyline

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Systems Biology

Background:

  • Lipidomics identifies and quantifies lipids (lipidome) and their interactions.
  • Mass spectrometry-based workflows are central to lipidomics and systems biology.
  • Bioinformatics infrastructure for lipidomics is currently limited.

Purpose of the Study:

  • To restructure and standardize bioinformatics tools for lipidomics.
  • To provide broad access to specialized lipidomics bioinformatics pipelines.
  • To foster research into lipid metabolic alterations and medical challenges.

Main Methods:

  • Development and standardization of search engines, quantification algorithms, and visualization tools.
  • Creation of accessible databases for lipidomics data.
  • Integration into the German Network for Bioinformatics (de.NBI) via the Bioinformatics for Proteomics (BioInfra.Prot) node.

Main Results:

  • A unified web-portal will offer access to restructured software, tutorials, and consulting services.
  • Capacity building in lipidomics informatics will be enhanced.
  • Improved bioinformatics support for lipidomics research.

Conclusions:

  • Standardized bioinformatics infrastructure is crucial for advancing lipidomics research.
  • Enhanced access to tools and resources will facilitate the study of lipid metabolism.
  • This initiative will support addressing medical challenges linked to lipid alterations.