Related Experiment Video
Updated: Feb 24, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
Matching complex dietary landscapes with the signalling pathways that regulate life history traits
Christen K Mirth1, Matthew Dw Piper2
1School of Biological Sciences, Monash University, Melbourne, Victoria 3800, Australia; Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal.
Abstract:
The rise in obesity in human populations has reinvigorated research focused on how nutrition impacts life history traits, including body size, lifespan, reproductive success, stress resistance and propensity for disease. Studies have ranged in their approach from identifying the molecular machinery responding to changes in nutrient levels, to understanding the hormonal changes that occur in response to diet, to mapping the response of differing life history traits over complex dietary landscapes. Connecting insights across these approaches presents significant challenges primarily because we lack information about how signalling pathways respond to dietary complexity. Here, we offer our perspective on how to integrate insights from the cellular to the whole organism to understand the regulation of life history traits.
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