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Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data
Yara Younan1, Anthony Martinez2, Nickolas Reimer3
1Department of Radiology and Imaging Sciences Section of Musculoskeletal Imaging, Emory University Hospital, 59 Executive Park South, 4th Floor Suite 4009, Atlanta, GA, 30329, USA.
Skeletal Radiology
|August 21, 2017
Summary
The spindle cell/pleomorphic lipoma spectrum presents imaging features that overlap with other fat-containing soft tissue masses. This study suggests including these lipomas in the differential diagnosis for such tumors, regardless of location or patient demographics.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Spindle cell/pleomorphic lipomas are soft tissue tumors.
- Imaging and clinical features of this lipoma spectrum are not well-defined.
- Distinguishing these lipomas from other fat-containing masses can be challenging.
Purpose of the Study:
- To compile the largest study on the imaging and clinical features of the spindle cell/pleomorphic lipoma spectrum.
- To evaluate the diagnostic utility of imaging features, demographics, and location in differentiating these lipomas.
- To advocate for the inclusion of spindle cell/pleomorphic lipomas in the differential diagnosis of fat-containing soft tissue masses.
Main Methods:
- Institutional search for classic spindle cell/pleomorphic lipomas with available data.
- Radiographic, anatomic, and clinical data analysis by a radiologist.
- Literature search combined with institutional data for a larger sample size.
Main Results:
- A total of 91 masses were analyzed (42 institutional, 49 from literature).
- 87% of masses were heterogeneous, 51% contained <75% fat, and 91% showed enhancement.
- Contrary to prior reports, 57% were subcutaneous, and neck/back regions accounted for 26%.
Conclusions:
- Imaging features, patient demographics, and tumor location are insufficient to differentiate spindle cell lipoma spectrum tumors.
- These lipomas should be considered in the differential diagnosis for all macroscopic fat-containing benign and malignant soft tissue tumors.
- This broadens the diagnostic considerations for radiologists evaluating soft tissue masses.
