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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Traumatic Memory01:20

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Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
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Dissociative Disorders01:27

Dissociative Disorders

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Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
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Related Experiment Video

Updated: Feb 24, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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Trauma, PTSD, and the Developing Brain.

Ryan J Herringa1

  • 1Department of Psychiatry, University of Wisconsin School of Medicine & Public Health, 6001 Research Park Blvd, Madison, WI, 53719, USA. herringa@wisc.edu.

Current Psychiatry Reports
|August 21, 2017
PubMed
Summary

Pediatric post-traumatic stress disorder (PTSD) shows altered brain development in youth. Neuroimaging reveals abnormal frontolimbic circuitry impacting threat processing and emotion regulation, requiring further longitudinal study.

Keywords:
AdolescentsChildrenNeurodevelopmentNeuroimagingPTSDTrauma

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Child Psychiatry

Background:

  • Pediatric post-traumatic stress disorder (PTSD) is a prevalent and impairing condition in youth.
  • The neurobiological underpinnings and developmental trajectory of pediatric PTSD remain less understood compared to adult PTSD.

Purpose of the Study:

  • To review recent neuroimaging findings in pediatric PTSD.
  • To discuss the implications of these findings for understanding neurodevelopmental alterations in youth with PTSD.
  • To identify future research directions.

Main Methods:

  • Review of recent neuroimaging studies focusing on pediatric PTSD.
  • Analysis of structural and functional brain alterations in youth with PTSD.
  • Examination of developmental trends in neural circuitry.

Main Results:

  • Pediatric PTSD is associated with abnormal structure and function in neural circuits involved in threat processing and emotion regulation.
  • Cross-sectional data suggest altered frontolimbic development in youth with PTSD, including declining hippocampal volume and increasing amygdala reactivity with age.
  • Abnormalities in amygdala-prefrontal coupling were also observed, potentially worsening with age.

Conclusions:

  • Pediatric PTSD exhibits both overt and developmental abnormalities in frontolimbic circuitry.
  • These neurodevelopmental changes may exacerbate threat reactivity and impair emotion regulation as children age.
  • Longitudinal studies are crucial to track individual outcomes and assess treatment efficacy in restoring healthy neurodevelopment.