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[Research Advances in the Epigenetics of Diffuse Large B-Cell Lymphoma-Review]
Chao-Yu Wang1, Chen Tian1, Yi-Zhuo Zhang1
1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer, Tianjin 300060,China.
Abstract:
The pathogenesis of diffuse large B-cell lymphoma(DLBCL) has not been fully elucidated, but people realized that the occurrence of DLBCL is caused by the mutual change of genetics and epigenetics with the rapid development of modern biological technology. Epigenetics is to explore the expression changes of genes and proteins without the changes of gene sequences, and this change is reversible and can be inherited. In this review, the latest advances of epigenetic changes in DNA methylation, microRNA regulation, and histone modification for DLBCL are summarized, so as to provide a new strategy to study the early diagnosis, treatment and prognosis of DLBCL.
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