[Research Progress of Mechanisms and Clinical Applications about MSC for Treating aGVHD-Review]

Yu Hui1, Fan Zhou1, Yi Zhang2

  • 1Training Base of Postgraduates, Jinzhou Medical University and General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.

Acute graft-versus-host disease (aGVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a significant cause of both morbidity and mortality in these patients. The unique immunomodulatory properties of mesenchymal stem cell (MSC) make them an invaluable cell type for treating GVHD. In this review, the clinical application and its mechamism of MSC are summarized.