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Updated: Feb 24, 2026

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro
Published on: September 18, 2017
[Research Advance on Promoting Angiogenesis of Mesenchymal Stem Cells-Review]
Qin-Qin Xu1, Ri-Li Ge2, Hui-Yan Sun3
1Institute of High Altitude Medicine, Qinghai University, Xining 810001, Qinghai Province, China; Qinghai People's Hospital, Xining 810007, Qinghai Province, China.
Abstract:
Mesenchymal stem cells (MSC) possess important biological characteristics of tissue repair and regeneration. MSC exert the properties promoting endogenous angiogenesis and have been widely applied in treatment of ischemia diseases. The therapeutic potency of MSC for ischemia diseases is owing to their secretion of angiogenic growth factors and release of exosomes. MSC promote angiogenesis stronger in hypoxia environment, and their miRNA played an important role in mediating regulation. This review summarizes recent advances in treatment of angiogenesis using MSC and their mechanisms. The angiogenic activities of MSC under hypoxia condition and their regulation by a miRNA network were discussed.
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