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Updated: Feb 24, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes
Sophie Jürgens1, Valeria Scalcon2, Natalia Estrada-Ortiz3
1Molecular Catalysis, Catalysis Research Centre and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, United Kingdom.
Abstract:
A family of cyclometalated Au(III) complexes featuring a tridentate C^N^C scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(C^N^C)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules.
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