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Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

Mahmut Huntürk Atilla1, Sibel Özdaş2, Talih Özdaş1

  • 1Yıldırım Beyazıt University, Yenimahalle Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey.

Brazilian Journal of Otorhinolaryngology
|August 22, 2017
PubMed

Insights

Genetic variations in the Ugrp2 gene are linked to an increased risk of adenoid hypertrophy in children. Specific Ugrp2 gene polymorphisms and their combinations significantly contribute to the development of this condition.

Area of Science:

  • Genetics
  • Pediatrics
  • Immunology

Background:

  • Adenoid hypertrophy, a common pediatric condition, involves chronic enlargement of adenoid tissues.
  • The Ugrp2 gene, involved in upper airway epithelial cell differentiation, has an unclear role in adenoid hypertrophy.
  • Limited research exists on the association between Ugrp2 genetic variations and adenoid hypertrophy.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the Ugrp2 gene and adenoid hypertrophy.
  • To explore the relationship between Ugrp2 gene variations and related clinical phenotypes of adenoid hypertrophy.

Main Methods:

  • A cohort of 219 children (114 with adenoid hypertrophy, 105 controls) was studied.
  • DNA sequencing was employed to determine Ugrp2 gene genotypes.
  • Statistical analyses, including haplotype and diplotype analyses, were performed.

Main Results:

  • Four Ugrp2 SNPs (IVS1-189G>A, IVS1-89T>G, c.201delC, IVS2-15G>A) were identified.
  • Specific Ugrp2 genotypes (TG, CdelC) and minor alleles showed increased risk for adenoid hypertrophy (p<0.05).
  • Ugrp2 haplotypes (GTdelCG, GTdelCA) and combined genotypes demonstrated significant associations (p<0.0001). Diplotypes with the c.201delC allele correlated with increased risk of adenoid hypertrophy with asthma and allergies (p<0.007).

Conclusions:

  • Certain Ugrp2 gene single nucleotide polymorphisms and their combinations are associated with an elevated risk of adenoid hypertrophy.
  • Genetic factors play a significant role in the pathogenesis of adenoid hypertrophy and its clinical manifestations.
  • This study highlights the importance of investigating genetic predispositions for adenoid hypertrophy.
Abstract

Keywords:
Adenoid hypertrophyAlergiaAllergyAsmaAsthmaHipertrofia de adenoidePolimorfismo de nucleotídeo únicoSingle nucleotide polymorphismUgrp2

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