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Polyacylurethanes as Novel Degradable Cell Carrier Materials for Tissue Engineering.

Danijela Jovanovic1, Frans V Roukes2, Andrea Löber3

  • 1Department of Polymer Science, Faculty of Mathematics and Natural Sciences, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. d.jovanovic@rug.nl.

Materials (Basel, Switzerland)
|August 22, 2017
PubMed
Summary

Newly developed polyacylurethanes (PAUs) offer a promising temporary scaffold for soft tissue repair, degrading controllably and supporting cell growth. These biodegradable materials show potential for short-term tissue engineering applications.

Keywords:
acylurethanesbiodegradable polymersbiomedical polyurethanesblood compatibilityendothelial cellshydrolytic degradationtissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polycaprolactone (PCL) based materials degrade slowly, limiting their use for short-term tissue engineering scaffolds.
  • A new class of polyacylurethanes (PAUs) has been developed to address the need for temporary, degradable scaffold materials.

Purpose of the Study:

  • To evaluate the in vitro degradation of PAUs.
  • To assess their suitability as temporary scaffold materials for soft tissue repair.

Main Methods:

  • In vitro degradation studies measuring mass loss and molar mass changes over 80 days.
  • Fourier Transform Infrared (FTIR) spectroscopy to analyze microphase separation.
  • In vitro haemocompatibility and cell culture studies (vascular endothelial cells) on PAU1000.
  • Contact angle measurements to assess surface properties.

Main Results:

  • PAUs exhibited controlled degradation via bulk and surface erosion, with 2.5-3.0% mass loss and ~35% molar mass decrease over 80 days.
  • The microphase separated morphology of PAU1000 provided favorable mechano-physical characteristics.
  • PAU1000 demonstrated excellent in vitro haemocompatibility and supported vascular endothelial cell adhesion and proliferation, further enhanced by fibronectin coating.
  • Degradation and incubation in biological fluids reduced the contact angle of PAU1000 to an optimal 60° for cell adhesion.

Conclusions:

  • PAUs degrade controllably, making them suitable for temporary scaffold applications.
  • PAU1000 possesses optimal properties for soft tissue repair, including good haemocompatibility and enhanced cell interaction.
  • These findings support the use of PAU1000 as a temporary degradable scaffold for soft tissue repair.