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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Feb 24, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
10:06

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

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Advances in High-Field BOLD fMRI.

Markus Barth1,2, Benedikt A Poser3,4

  • 1Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen 6525 HP, The Netherlands. markus.barth@donders.ru.nl.

Materials (Basel, Switzerland)
|August 22, 2017
PubMed
Summary

High-field 7 Tesla BOLD fMRI offers high resolution and whole-brain coverage. Technical challenges have been overcome, enabling detailed structure-function mapping and future connectivity studies.

Keywords:
2D EPI3D EPI7 TeslaBOLD fMRIBOLD responsehigh field

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging

Background:

  • Blood-Oxygen-Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) is a key neuroimaging technique.
  • High magnetic field strengths, such as 7 Tesla (7T), offer potential for improved BOLD fMRI performance.

Purpose of the Study:

  • To review the current status of 7T BOLD fMRI.
  • To discuss technical advancements, challenges, and future applications.

Main Methods:

  • Review of BOLD contrast mechanisms, resolution, sensitivity, and specificity at 7T.
  • Examination of technical developments in array coils, imaging sequences, and parallel imaging reconstruction.

Main Results:

  • Key technical challenges for 7T BOLD fMRI have been successfully addressed.
  • High-resolution BOLD fMRI protocols now achieve whole-brain coverage with repetition times (TR) under 3 seconds.
  • Detailed structural information aids in co-localizing brain structure and function.

Conclusions:

  • 7T BOLD fMRI is a mature technique with significant potential.
  • Future applications include laminar resolution whole-brain connectivity analysis and single-subject studies.