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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Feb 24, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
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Mesenchymal Stem Cell Therapy for Ischemic Stroke.

Atsuhiko Toyoshima1, Takao Yasuhara, Isao Date

  • 1Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.atsuhiko.t@kyj.biglobe.ne.jp.

Acta Medica Okayama
|August 22, 2017
PubMed
Summary

Mesenchymal stem cell (MSC) transplantation shows promise for treating ischemic stroke, with studies confirming its safety and neuroprotective benefits in patients. Further research into optimal transplantation methods is crucial for clinical success.

Keywords:
cell transplantationischemic strokeclinical trialmesenchymal stem cell

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Neurology

Background:

  • Animal and clinical studies suggest mesenchymal stem cell (MSC) transplantation offers neuroprotection in ischemic stroke.
  • Existing research highlights the safety and feasibility of MSC therapy for stroke patients.

Purpose of the Study:

  • To review current approaches and mechanisms of MSC transplantation for ischemic stroke.
  • To summarize findings from clinical studies on MSC therapy in ischemic stroke patients.
  • To explore the safety profile of MSC transplantation.

Main Methods:

  • Literature review of animal and clinical studies on MSC transplantation in ischemic stroke.
  • Analysis of proposed mechanisms underlying MSC therapeutic effects.
  • Synthesis of data from ongoing and completed clinical trials.

Main Results:

  • MSC transplantation demonstrates significant neuroprotective effects in both animal models and human patients with ischemic stroke.
  • Clinical studies confirm the safety and feasibility of this therapeutic approach.
  • Key therapeutic mechanisms include anti-inflammatory, anti-apoptotic, and pro-angiogenic effects.

Conclusions:

  • Mesenchymal stem cell therapy is a promising future treatment for ischemic stroke.
  • Optimizing transplantation timing, approach, and cell dosage is essential for effective clinical application.
  • MSC therapy holds potential for improving patient outcomes after ischemic stroke.