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Updated: Feb 24, 2026
A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
Published on: November 23, 2015
Optical methods for quantitative and label-free sensing in living human tissues: principles, techniques, and
Robert H Wilson1, Karthik Vishwanath2, Mary-Ann Mycek3
1Beckman Laser Institute, University of California, Irvine, Irvine, CA, USA.
Abstract:
We present an overview of quantitative and label-free optical methods used to characterize living biological tissues, with an emphasis on emerging applications in clinical tissue diagnostics. Specifically, this review focuses on diffuse optical spectroscopy, imaging, and tomography, optical coherence-based techniques, and non-linear optical methods for molecular imaging. The potential for non- or minimally-invasive assessment, quantitative diagnostics, and continuous monitoring enabled by these tissue-optics technologies provides significant promise for continued clinical translation.
