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Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation
Tyler Novak1, Benjamin Seelbinder1, Celina M Twitchell1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Advanced Functional Materials
|August 22, 2017
Abstract:
Decellularized cartilage microparticles, and all associated native signals, are delivered to hMSC populations in a dense, type I collagen matrix. Hybrid usage of native tissue signals and the engineering control of collagen matrices show the ability to induce local infiltration and differentiation of hMSCs. Additionally, the solid cartilage microparticles inhibit bulk cell-mediated contraction of the composite.
