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Microfluidics in Assessing Platelet Function
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Why Do Patients Bleed?

Jennifer Curnow1, Leonardo Pasalic1,2, Emmanuel J Favaloro1,2

  • 1Department of Clinical and Laboratory Hematology, Institute of Clinical Pathology and Medical Research and Westmead Hospital, Sydney Centres for Thrombosis and Hemostasis, Westmead, Australia.

Surgery Journal (New York, N.Y.)
|August 22, 2017
PubMed
Summary
This summary is machine-generated.

Unexpected bleeding during surgery can stem from anatomical issues, medications, or hemostasis disorders. This review guides perioperative screening, investigation, and management of non-surgical bleeding causes.

Keywords:
bleedingcoagulationhemostasisplatelet functionsurgery

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Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Hematology
  • Surgical Sciences

Background:

  • Patients undergoing surgery may experience unexpected bleeding.
  • Surgical causes are excluded, necessitating investigation into other factors.
  • Potential causes include anatomical anomalies, drug intake, and hemostasis disorders.

Purpose of the Study:

  • To review reasons for perioperative bleeding.
  • To provide guidance on screening for bleeding conditions.
  • To offer strategies for investigating and managing unexpected bleeding.

Main Methods:

  • Literature review of perioperative bleeding.
  • Analysis of patient history and examination findings.
  • Guidance on diagnostic investigations and management protocols.

Main Results:

  • Identified structural anomalies, drug effects, and hemostasis disorders as key non-surgical bleeding causes.
  • Emphasized the importance of pre-operative assessment.
  • Outlined diagnostic pathways for acquired and congenital hemostasis disorders.

Conclusions:

  • Comprehensive pre-operative evaluation is crucial for identifying patients at risk of bleeding.
  • Systematic investigation and management are essential for addressing perioperative bleeding.
  • Understanding non-surgical bleeding etiologies improves patient safety and outcomes.