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Updated: Feb 24, 2026
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
Published on: November 12, 2017
Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment
Gabriel Velez1,2,3, C Nathaniel Roybal1,2, Elaine Binkley2
1Omics Laboratory, University of Iowa, Iowa City, IA.
Purpose:
To report a case of elevated intraocular pressure with retinal detachment.
Observations:
Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology.
Conclusions And Importance:
Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.
