Cobalt-Catalyzed Oxidant-Free Spirocycle Synthesis by Liberation of Hydrogen
Ningning Lv1, Yue Liu1, Chunhua Xiong2
1Department of Chemistry, Zhejiang University , Hangzhou 310027, China.
Abstract:
The first example of oxidant-free cobalt-catalyzed synthesis of five-membered spirocycles is reported from benzimidates and maleimides utilizing nitrobenzene as promoter. In contrast to previously known cobalt-catalyzed oxidative C-H functionalization reactions, this transformation occurs efficiently in the absence of oxidant and is accompanied by liberation of hydrogen. The spiro-lactams were readily achieved by the hydrolysis of as-prepared spirocyclic compounds. The Cp*Rh(III) catalyst shows poor reactivity.
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