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The prognosis following amphetamine poisoning.
Henrik Horwitz1, Kim P Dalhoff1, Marc Klemp2,3
11 The Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Denmark.
Scandinavian Journal of Public Health
|August 22, 2017
Summary
Amphetamine poisoning leads to significantly higher long-term mortality and social problems. Individuals poisoned by amphetamines face a poor prognosis with increased risks of psychiatric disorders and co-morbidities.
Area of Science:
- Toxicology
- Public Health
- Psychiatry
Background:
- Amphetamine poisoning presents significant public health challenges.
- Long-term outcomes and associated co-morbidities require further investigation.
Purpose of the Study:
- To investigate long-term mortality following amphetamine or substituted amphetamine poisoning.
- To examine social problems and co-morbidities impacting survival post-amphetamine poisoning.
Main Methods:
- Utilized Danish national registries to track 1444 amphetamine-poisoned patients (2006-2013).
- Correlated patient data with social and health registries, comparing outcomes against 100 matched controls per case.
- Analyzed factors influencing mortality, including gender, age, and pre-existing conditions.
Main Results:
- 11% of amphetamine poisoning patients died within seven years, compared to 0.6% in controls.
- Psychiatric disorders, HIV, and previous incarceration were ~10 times more prevalent.
- Male gender, age, opioid dependence, schizophrenia, affective disorders, and HIV were linked to increased mortality.
Conclusions:
- Amphetamine poisoning is associated with a poor long-term prognosis.
- Significant social and health-related deterioration complicates recovery and survival.
- Early intervention and comprehensive support are crucial for affected individuals.