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Protective immunity against tuberculosis: what does it look like and how do we find it?
1Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States.
Current Opinion in Immunology
|August 22, 2017
Summary
Developing tuberculosis vaccines requires understanding immune responses. Microbial reporters can reveal how host cells affect bacterial growth, aiding vaccine and therapeutic development for tuberculosis control.
Area of Science:
- Immunology
- Microbiology
- Vaccinology
Background:
- Tuberculosis (TB) vaccine development is hindered by a lack of reliable immune protection markers.
- Limited understanding exists regarding immune mechanisms controlling TB disease progression versus containment.
Purpose of the Study:
- To discuss the utility of microbial readouts of bacterial fitness.
- To investigate host immune environments and identify cell subsets influencing bacterial growth.
- To highlight the importance of this knowledge for TB vaccine and therapeutic strategies.
Main Methods:
- Utilizing microbial reporters to assess bacterial fitness within host environments.
- Probing host immune cell subsets for their role in promoting or controlling bacterial growth.
Main Results:
- Bacterial reporters offer a novel approach to study host-pathogen interactions in TB.
- Identification of specific host cell subsets that either support or inhibit Mycobacterium tuberculosis growth.
Conclusions:
- Microbial readouts are crucial for understanding immune mechanisms underlying TB disease outcomes.
- This approach is vital for developing effective tuberculosis vaccines and immune-modulatory therapies.
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