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Related Experiment Videos

[Partial mechanical cardiac replacement in experimental cardiogenic shock].

F Stellwag

    Wiener Klinische Wochenschrift. Supplementum
    |January 1, 1979
    PubMed
    Summary

    This study evaluates artificial ventricles for left heart assist during cardiogenic shock. The pneumatically driven ellipsoid ventricle (ELVAD) significantly improved hemodynamic parameters in calf models, demonstrating its potential for circulatory support.

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    [Influencing of the kininogen-Kinin-System by means of a kallikrein-inhibitor during extracorporeal circulation in open heart surgery (author's transl)].

    Der Anaesthesist·1977

    Area of Science:

    • Cardiovascular Research
    • Biomedical Engineering
    • Surgical Innovation

    Context:

    • Cardiogenic shock necessitates advanced circulatory support systems.
    • Current models for assisted circulation research have limitations.
    • Evaluating artificial ventricles is crucial for left heart assistance.

    Purpose:

    • To assess the efficacy of the pneumatically driven ellipsoid ventricle (ELVAD) in managing cardiogenic shock.
    • To present a novel method for inducing cardiogenic shock: selective peripheral coronary embolization.
    • To analyze the hemodynamic effects of ELVAD support in a preclinical model.

    Summary:

    • A selective peripheral coronary embolization model was developed using polyester fibrils.
    • Twenty acute calf experiments demonstrated ELVAD's impact on hemodynamics during shock.
    • ELVAD insertion led to decreased left ventricular and atrial pressures, increased cardiac index and mean aortic pressure.

    Impact:

    • The study provides critical data on ELVAD performance in a cardiogenic shock scenario.
    • Findings support the potential of ELVAD as a viable option for left heart mechanical circulatory support.
    • Analysis of hemodynamics during irreversible ventricular fibrillation highlights ELVAD's extended support capability.

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