Related Experiment Video
Updated: Feb 24, 2026
07:03
Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
Published on: October 2, 2020
5.2K
Nanocarrier based approaches for targeting breast cancer stem cells
Sai Kiran S S Pindiprolu1, Praveen T Krishnamurthy1, Pavan Kumar Chintamaneni1
1a Department of Pharmacology , JSS College of Pharmacy (A Constituent College of Jagadguru Sri Shivarathreeshwara University) , Ootacamund , Tamil Nadu , India.
Artificial Cells, Nanomedicine, and Biotechnology
|August 23, 2017
Summary
Targeting breast cancer stem cells (BCSCs) is crucial for preventing tumor relapse. Nanotechnology offers promising solutions for delivering anti-BCSC agents effectively, overcoming current limitations.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Breast cancer stem cells (BCSCs) drive tumor initiation and relapse.
- BCSCs survive chemotherapy, limiting treatment efficacy.
- Current anti-BCSC agents face challenges like off-target effects and poor bioavailability.
Purpose of the Study:
- To review strategies for targeting BCSCs using nanocarriers.
- To highlight the potential of nanotechnology in overcoming drug delivery limitations for BCSCs.
Main Methods:
- Literature review of nanocarrier-based strategies for BCSC targeting.
- Analysis of nanocarrier advantages in overcoming drug bioavailability and specificity issues.
Main Results:
- Nanocarriers can enhance the specific delivery of anti-BCSC agents.
- Nanotechnology addresses bioavailability and off-target effect limitations of current therapies.
Conclusions:
- Nanocarrier-based drug delivery presents a promising approach for eradicating BCSCs.
- Targeting BCSCs with nanocarriers is essential for achieving a radical cure in breast cancer.
Related Concept Videos
02:40Cancer Stem Cells and Tumor Maintenance
6.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.1K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K