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Simple tumor enucleation may not decrease oncologic outcomes for T1 renal cell carcinoma: A systematic review and

De-Hong Cao¹, Liang-Ren Liu¹, Yu Fang¹

¹Department of Urology, Institute of Urology, West China Hospital, SiChuan University, Chengdu, China.

Urologic Oncology

|August 23, 2017

Summary

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Simple tumor enucleation (TE) is a safe and effective treatment for T1 renal tumors, offering shorter operation times and less blood loss compared to traditional partial nephrectomy (PN). Early oncologic outcomes for TE are acceptable, though further research is needed.

Area of Science:

Urology
Nephrology
Surgical Oncology

Background:

Renal cell carcinoma (RCC) is a common malignancy, with T1 stage representing early-stage disease.
Partial nephrectomy (PN) is the standard surgical approach for T1 RCC, aiming to preserve renal function.
Tumor enucleation (TE) is an alternative minimally invasive technique for T1 RCC.

Purpose of the Study:

To evaluate the clinical efficacy and safety of simple tumor enucleation (TE) compared to traditional partial nephrectomy (PN).
To assess oncologic outcomes and perioperative parameters for TE in T1 renal cell carcinoma.

Main Methods:

A systematic literature search was conducted across PubMed, EMBASE, and Cochrane Central Register of Controlled Trials.
Included studies compared TE and traditional PN for clinical T1 renal cell carcinoma.

Keywords:

Meta-analysis Partial nephrectomy Renal cell carcinoma Tumor enucleation

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A meta-analysis of 7 studies involving 3,218 patients was performed.

Main Results:

TE demonstrated significantly shorter operation times, warm ischemia times, and less blood loss compared to PN.
Surgical complication rates were significantly lower in the TE group.
No significant differences were observed in hospital stay, estimated glomerular filtration rate changes, positive surgical margin rates, or local recurrence rates between TE and PN.

Conclusions:

Simple tumor enucleation (TE) is an effective and safe treatment option for T1 renal tumors.
TE offers favorable perioperative outcomes and acceptable early oncologic results compared to traditional PN.
Further well-designed prospective studies are warranted to confirm these findings due to the limitations of current data.