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Preoperative Aspirin Does Not Increase Transfusion or Reoperation in Isolated Valve Surgery

Jordan E Goldhammer1, Corey R Herman1, Mark W Berguson1

  • 1Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Philadelphia, PA.

Journal of Cardiothoracic and Vascular Anesthesia
|August 23, 2017
PubMed

Insights

Preoperative aspirin use in elective heart valve surgery did not increase bleeding or transfusion rates. This study found no significant difference in major adverse events or mortality for patients taking aspirin before surgery.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Pharmacology

Background:

  • Preoperative aspirin use is common in cardiac surgery patients.
  • Limited data exists on aspirin's impact in valve surgery compared to coronary artery bypass graft surgery.

Purpose of the Study:

  • To investigate the effects of preoperative aspirin on bleeding and transfusion requirements in patients undergoing elective, isolated heart valve repair or replacement.

Main Methods:

  • Retrospective cohort study of 488 patients undergoing non-emergent, isolated valve surgery.
  • Patients were divided into two groups: those taking aspirin preoperatively (n=282) and those not (n=206).
  • Logistic regression analysis was used to compare outcomes between groups.

Main Results:

  • No significant differences were observed in red blood cell (RBC) transfusion rates, mean RBC units transfused, or massive transfusion requirements.
  • Aspirin use was not associated with an increased rate of re-exploration for bleeding (5.3% vs. 6.3%, p=0.478).
  • Major adverse cardiocerebral events (MACE), 30-day mortality, and 30-day readmission rates were similar between groups.

Conclusions:

  • Preoperative aspirin therapy in elective, isolated valve surgery does not increase transfusion or reoperation for bleeding.
  • Aspirin therapy was not associated with reduced readmission rates, MACE, or 30-day mortality in this patient population.
Abstract

Keywords:
aspirinbleedingcardiac surgeryreoperationtransfusionvalve surgery

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