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Related Experiment Videos

Opiate anaesthesia.

T H Stanley

    Anaesthesia and Intensive Care
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Opioid anesthesia, especially fentanyl, offers cardiovascular stability for cardiac surgery. While effective, high doses of opioids do not fully mitigate stress responses during cardiopulmonary bypass.

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    Area of Science:

    • Anesthesiology
    • Cardiovascular Anesthesia
    • Pharmacology

    Background:

    • Opioids are widely used in anesthesia.
    • Opioid anesthesia techniques are increasingly popular in cardiovascular anesthesia.
    • Understanding opioid effects on hemodynamics and stress response is crucial.

    Purpose of the Study:

    • To review the current use of opioids in anesthesia, focusing on anesthetic doses.
    • To evaluate the suitability of different opioids for cardiovascular anesthesia.
    • To assess the impact of high-dose opioids on hormonal and metabolic stress responses.

    Main Methods:

    • Literature review of opioid use in anesthesia.
    • Emphasis on anesthetic doses and cardiovascular anesthesia techniques.

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  • Analysis of cardiovascular stability, hemodynamic disturbances, and stress response modulation.

    • Main Results:

    • Fentanyl provides significant cardiovascular stability, even in patients with impaired cardiac function.
    • Morphine and pethidine are associated with higher risks of cardiovascular disturbances in high doses.
    • Sufentanil and alfentanil show potential as suitable alternatives.
    • High-dose opioids reduce but do not eliminate hormonal and metabolic stress responses to surgery, particularly catecholamine increases during cardiopulmonary bypass.

    Conclusions:

    • Opioid anesthesia, particularly with fentanyl, is beneficial for cardiovascular stability during surgery.
    • Careful selection of opioids is necessary for cardiovascular surgery due to potential hemodynamic effects.
    • While opioids modulate stress responses, they do not completely abolish them, and effects may not persist postoperatively.