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Related Experiment Videos

I.v. temazepam: theoretical and clinical considerations.

N J Halliday, J W Dundee, R J Carlisle

    British Journal of Anaesthesia
    |April 1, 1987
    PubMed
    Summary

    Injectable temazepam formulations showed significant drawbacks, including venous thrombosis and reduced sedative potency. Oral elixir offered faster absorption than capsules, but injectable forms required higher doses for sedation.

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    Area of Science:

    • Pharmacology
    • Anesthesiology

    Background:

    • Temazepam is a benzodiazepine used for sedation.
    • Investigating novel injectable formulations of temazepam is crucial for optimizing its clinical application.

    Purpose of the Study:

    • To evaluate the safety and efficacy of two injectable temazepam formulations (propylene glycol and salicylic acid).
    • To compare the pharmacokinetic profiles of oral (capsule, elixir) and intravenous (IV) temazepam.
    • To assess the sedative potency of IV temazepam and its effect on thiopental induction dose.

    Main Methods:

    • Volunteers and surgical patients received oral (capsule, elixir) and IV temazepam formulations.
    • Plasma concentrations were monitored.
    • Sedative effects and thiopental induction doses were recorded.

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    Main Results:

    • The salicylic acid injectable preparation was painful; both IV formulations led to high rates of venous thrombosis.
    • Oral elixir showed faster temazepam absorption than capsules.
    • IV temazepam exhibited lower-than-expected sedative potency, requiring doses >0.6 mg/kg.
    • IV temazepam significantly reduced the thiopental induction dose.

    Conclusions:

    • Injectable temazepam formulations pose significant safety concerns (pain, thrombosis) and have reduced sedative efficacy.
    • Oral elixir provides more rapid absorption compared to capsules.
    • IV temazepam can reduce the dose of other anesthetic agents like thiopental.