Comparative experimental study on two designed intravenous anaesthetic combinations in dogs

Area of Science:

• Veterinary Anesthesiology
• Comparative Pharmacology

Background:

• Optimizing anesthetic protocols in dogs is crucial for minimizing post-operative complications.
• Evaluating novel anesthetic combinations is essential for improving patient outcomes in veterinary medicine.

Purpose of the Study:

• To design and compare two anesthetic regimens for optimal anesthesia in dogs.
• To assess the efficacy and safety of anesthetic combinations involving ketamine and propofol.

Main Methods:

• Two anesthetic combinations were administered to Mongrel dogs: Combination A (atropine, xylazine, ketamine, propofol) and Combination B (atropine, diazepam, ketamine, propofol).
• Key parameters including anesthetic onset, duration, recovery time, heart rate, respiratory rate, body temperature, and blood picture were recorded and analyzed.

Main Results:

• Combination A demonstrated rapid anesthetic induction (seconds) and maintenance (29 minutes) with a smooth recovery (68 minutes).
• Combination B exhibited slower induction (14 minutes), shorter maintenance (23 minutes), and was associated with significant physiological alterations.
• Combination A resulted in minimal adverse effects compared to Combination B.

Conclusions:

• The combination of atropine, xylazine, ketamine, and propofol (Combination A) provides satisfactory anesthesia in dogs.
• This anesthetic protocol is recommended for veterinary use due to its rapid onset, effective maintenance, smooth recovery, and minimal side effects.