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Updated: Feb 24, 2026
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with
Xin Du1, Linlin Liu1, Yongxin Yang2
1Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital Tianjin China.
Introduction:
Internet gaming disorder (IGD) is usually defined as the inability of an individual to control internet gaming resulting in serious negative consequences, and trait impulsivity has been viewed as a hallmark feature of IGD. Recent studies have suggested that the structural integrity of the white matter (WM) plays an important role in the neuromediation of an individual's impulsivity. However, no study has examined the association between WM integrity and impulsivity in IGD adolescents.
Methods:
In this study, 33 adolescents with IGD and 32 healthy controls (HCs) were recruited, and the intergroup differences in the relationships between impulsivity and fractional anisotropy (FA) values across the whole brain WM were investigated using voxel-wise correlation analyses.
Results:
Our results revealed significant intergroup differences in the correlations between impulsivity and the FA values of the right corticospinal tract (CST) and the right occipital WM. Region of interest-based tests revealed that the FA values of these clusters were positive or insignificantly correlated with impulsivity in the IGD adolescents contrasted to the significantly negative correlation in the HCs.
Conclusions:
This altered correlations in the IGD adolescents might reflect potential WM microstructural changes which may be associated with the greater impulsivity of IGD adolescents and provide possible therapeutic targets for interventions in this population.
