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Maternal consumption of quinine-containing sodas may induce G6PD crises in breastfed children

S Bichali1, D Brault2, C Masserot3

  • 1Department of Pediatric Intensive Care, Nantes University Hospital, Nantes, France.

European Journal of Pediatrics
|August 23, 2017
PubMed

Insights

Maternal consumption of quinine-containing tonic drinks can trigger Glucose-6-phosphate dehydrogenase (G6PD) deficiency crises in breastfed infants. Avoid these beverages during breastfeeding in G6PD-prevalent populations to prevent hemolytic anemia.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Toxicology

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder.
  • Hemolytic events in G6PD deficiency are often triggered by pro-oxidant agents.
  • Neonatal jaundice and hemolytic anemia are common presentations of G6PD deficiency.

Observation:

  • Three cases of G6PD crises in breastfed infants were observed.
  • The crises were linked to maternal consumption of tonic drinks containing quinine.
  • Quinine was detected in breast milk, confirming transmission.

Findings:

  • Maternal intake of quinine via tonic drinks can lead to G6PD crises in exclusively breastfed infants.
  • The concentration of quinine in breast milk is sufficient to induce hemolytic events.
  • This highlights a novel pro-oxidant trigger for G6PD deficiency.

Implications:

  • Healthcare providers should counsel breastfeeding mothers in G6PD-prevalent areas about avoiding quinine-containing beverages.
  • This finding expands the understanding of environmental triggers for G6PD-related hemolysis.
  • Preventive measures can mitigate the risk of severe neonatal complications in infants with G6PD deficiency.

Keywords:
BreastfeedingChildrenGlucose-6-phosphate dehydrogenaseQuinineTonic drink

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