Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Embryonal central neuroepithelial tumors: current concepts and future challenges.

S R Vandenberg, M M Herman, L J Rubinstein

    Cancer Metastasis Reviews
    |January 1, 1987
    PubMed
    Summary

    Advances in neurohistology distinguish embryonal central nervous system (CNS) tumors. Four tumors show multipotential differentiation, suggesting developmental abnormalities influence their behavior.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pro-angiogenic cellular and genomic expression patterns within glioblastoma influences dynamic susceptibility weighted perfusion MRI.

    Clinical radiology·2015
    Same author

    Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.

    Oncogene·2014
    Same author

    APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.

    Molecular psychiatry·2014
    Same author

    Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain.

    Molecular psychiatry·2013
    Same author

    Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype.

    Molecular psychiatry·2010
    Same author

    Contiguous Sarcomatous and Gliomatous Tissue in Intracranial Tumours [Abstract].

    Proceedings of the Royal Society of Medicine·2009

    Area of Science:

    • Neuro-oncology
    • Developmental Neuroscience
    • Cell Biology

    Background:

    • Embryonal central nervous system (CNS) tumors pose significant clinical challenges.
    • Recent advancements in neurohistological, immunohistochemical, and immunocytochemical techniques enable the identification of distinct cytomorphogenetic entities.
    • These entities often mirror normal neurocytogenesis phases.

    Purpose of the Study:

    • To explore the cytomorphogenetic classification of embryonal CNS tumors.
    • To investigate the role of developmental regulatory mechanisms in tumor behavior.
    • To hypothesize the involvement of growth factors and neuroregulatory neurotransmitters in tumor modulation.

    Main Methods:

    • Utilizing advanced neurohistological, immunohistochemical, and immunocytochemical techniques for cell type identification.

    Related Experiment Videos

  • Analyzing cytomorphogenetic, clinical, and experimental data.
  • Reviewing existing knowledge on growth factors and neuroregulatory neurotransmitters in normal neuromorphogenesis.

    • Main Results:

    • Four specific tumors (medulloepithelioma, desmoplastic infantile ganglioglioma, pineoblastoma, medulloblastoma) are identified as multipotential due to divergent differentiation capacity.
    • Evidence suggests fetal neural cell targets are implicated in tumor transformation.
    • Aberrant developmental regulatory mechanisms are proposed contributors to tumor biology.

    Conclusions:

    • Embryonal CNS tumors may be influenced by growth factors and neuroregulatory neurotransmitters through receptor interactions.
    • Future research should focus on defining new tumor entities and subgroups based on molecular markers.
    • Characterizing neoplastic receptor responses to growth factors and neurotransmitters is crucial for understanding tumor growth and maturation potential.