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Drug interactions with the calcium-entry blockers.

R W Piepho, V L Culbertson, R S Rhodes

    Circulation
    |June 1, 1987
    PubMed
    Summary

    Calcium-entry blockers can interact with many drugs, especially cardiovascular agents. Careful dose adjustment allows for safe combination therapy, minimizing risks associated with drug interactions.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Cardiovascular Medicine

    Background:

    • Calcium-entry blockers are widely prescribed, increasing the risk of drug interactions.
    • Interactions with cardiovascular drugs are particularly concerning due to potential synergistic negative effects on heart function.

    Purpose of the Study:

    • To assess the clinical relevance of drug interactions involving calcium-entry blockers.
    • To evaluate interactions with cardiac glycosides, beta-blockers, antiarrhythmics, and other calcium-entry blockers.
    • To examine interactions with H2-receptor antagonists, anticonvulsants, lithium, anesthetics, cytostatics, rifampin, and sulfinpyrazone.

    Main Methods:

    • Review of clinical relevance of reported drug interactions.
    • Evaluation of interactions with various drug classes.
    • Consideration of dose modifications for concurrent use of social drugs like alcohol and tobacco.

    Main Results:

    • Numerous potential drug interactions exist for calcium-entry blockers.
    • Interactions with cardiovascular agents pose significant risks to cardiac function.
    • Dose adjustments are crucial for managing concurrent social drug use.

    Conclusions:

    • Combination therapy with calcium-entry blockers is feasible.
    • Appropriate dose modification is essential for safe and effective concomitant drug use.
    • Understanding and managing drug interactions is key to optimizing calcium-entry blocker therapy.

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