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Updated: Feb 24, 2026

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Published on: February 24, 2021
Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation
Yvonne Reinders1,2, Oliver Felthaus3, Gero Brockhoff4
1Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany. yvonne.reinders@ukr.de.
Abstract:
Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.
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