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Hyperphosphataemia in histamine injected laying hens.
Summary
Histamine affects calcium and phosphorus levels in laying hens during eggshell formation. This suggests bone resorption increases due to reduced intestinal calcium, impacting egg production.
Area of Science:
- Animal Physiology
- Biochemistry
- Reproductive Biology
Background:
- Eggshell formation requires significant calcium mobilization.
- Histamine is implicated in various physiological processes, including bone metabolism.
- Understanding calcium and phosphorus regulation is crucial for poultry production.
Purpose of the Study:
- To investigate the effects of histamine on calcium and phosphorus metabolism in laying hens.
- To determine the role of histamine in modulating gastrointestinal calcium during eggshell formation.
- To explore the potential involvement of histamine in bone resorption related to egg production.
Main Methods:
- Administered histamine to laying hens during the eggshell formation period.
- Measured soluble calcium in gastrointestinal contents.
- Assessed plasma inorganic phosphorus, free-hydroxyproline, and urinary phosphorus levels.
- Utilized cimetidine to block histamine effects.
Main Results:
- Histamine administration led to decreased soluble gastrointestinal calcium levels.
- Hyperphosphataemia and hyperhydroxyprolinemia were observed 3 hours post-histamine injection.
- Cimetidine successfully inhibited all histamine-induced effects.
- These findings link histamine to altered calcium and phosphorus homeostasis.
Conclusions:
- Histamine significantly impacts calcium and phosphorus metabolism in laying hens.
- Reduced soluble intestinal calcium induced by histamine may trigger increased bone resorption.
- This mechanism is likely crucial during the high calcium demand of eggshell formation.
- Histamine antagonism can prevent these metabolic disturbances.