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Tramadol-associated mania: A case report.

Jamaluddin Nimah¹, Alexander Chen², Kelly N Gable³

¹Department of Medicine, University of California at Los Angeles, Los Angeles, California.

Journal of Opioid Management

|August 23, 2017

Summary

This summary is machine-generated.

Antidepressants and tramadol can trigger mania in bipolar disorder patients. This case highlights tramadol-induced mania in a patient without diagnosed bipolar disorder, suggesting a potential link to monoamine neurotransmission.

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Medications like tricyclic antidepressants and venlafaxine are known triggers for manic episodes in individuals with bipolar disorder.
The synthetic opioid tramadol has also been linked to mania activation.

Observation:

This report details an atypical case of tramadol-associated mania.
The patient presented without a diagnosed history of bipolar disorder.
She had experienced two previous manic episodes after tramadol use, previously attributed to medication-induced mood disorder.

Findings:

Tramadol can induce manic episodes even in individuals without a pre-existing bipolar disorder diagnosis.
Recurrent tramadol-associated mania suggests a potential medication-specific effect rather than solely an underlying psychiatric condition.

Implications:

The findings suggest a need for careful monitoring of patients, even those without a bipolar disorder diagnosis, when prescribing tramadol.
Further research into the neurobiological mechanisms, potentially involving monoamine neurotransmission and oxidative stress, is warranted to understand tramadol-induced mania.