Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents
James W Marsh1, Karrera Y Djoko2, Alastair G McEwan2
1The iThree Institute, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Abstract:
Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.
More Related Videos
Related Concept Videos
Complexation Equilibria: The Chelate Effect
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
EDTA: Chemistry and Properties
Bacterial Phylum Chlamydiae
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexometric Titration: Ligands


