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Using murine colitis models to analyze probiotics-host interactions.

Rebeca Martín1, Florian Chain1, Sylvie Miquel2

  • 1INRA, Commensals and Probiotics-Host Interactions Laboratory, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.

FEMS Microbiology Reviews
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Summary
This summary is machine-generated.

This review explores murine colitis models for testing probiotics. Proper model selection is crucial for evaluating probiotic efficacy and safety in conferring host health benefits.

Keywords:
DSSTNBSadoptive cell transfer colitisinfectious colitisinflammatory bowel diseasespontaneous colitis

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Probiotics are live microorganisms conferring health benefits.
  • Criteria for probiotics include demonstrated efficacy, safety, and survival through the GI tract.
  • Murine colitis models are vital for in vivo probiotic research.

Purpose of the Study:

  • To review current murine colitis models for probiotic testing.
  • To provide an overview of probiotics already evaluated in these models.
  • To emphasize the importance of appropriate model selection and in vivo data.

Main Methods:

  • Literature review of murine colitis models.
  • Compilation of data on tested probiotic strains.
  • Analysis of model suitability for probiotic evaluation.

Main Results:

  • Various murine colitis models are available for probiotic research.
  • A range of probiotic strains have been tested for their effects.
  • Model selection significantly impacts the interpretation of probiotic efficacy.

Conclusions:

  • Appropriate selection of murine models is essential for accurate probiotic assessment.
  • In vivo studies using well-chosen models provide valuable data on probiotic potential.
  • Further research should focus on optimizing model-host-probiotic interactions.