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Ginseng on Nuclear Hormone Receptors
Joonwoo Park1, Phuong T C Bui1, Heewon Song1
1* Department of Bioscience and Biotechnology, College of Life Science, Sejong University, Kwangjingu, Kunjadong, Seoul 04310, Republic of Korea.
The American Journal of Chinese Medicine
|August 24, 2017
Summary
Ginseng
Area of Science:
- Pharmacology and Molecular Biology
- Herbal Medicine Research
Background:
- Ginseng has a long history of use, with ginsenosides identified as key active compounds.
- Ginseng's bioactive ingredients are increasingly linked to the regulation of nuclear receptors and signaling pathways.
Purpose of the Study:
- To review the literature on ginseng's effects on nuclear hormone receptors.
- To explore ginseng's potential in treating diseases like cancer, obesity, and cardiovascular/neurological disorders.
Main Methods:
- Literature review of studies on ginseng, ginsenosides, and nuclear receptors.
- Analysis of ginseng's impact on estrogen, glucocorticoid, peroxisome proliferator-activated, and androgen receptors.
Main Results:
- Evidence suggests nuclear receptors are cellular targets of ginsenosides.
- Ginseng constituents influence signaling pathways like ERK and PI3K/Akt.
Conclusions:
- Ginsenosides interact with nuclear receptors, mediating biological functions.
- Further rigorous research is needed to scientifically validate ginseng's therapeutic efficacy.
Keywords:
Androgen ReceptorEstrogen ReceptorGlucocorticoid ReceptorNuclear Hormone ReceptorsPanax ginsengPeroxisome Proliferator-Activated ReceptorReviewMore Related Videos
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