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Using biomarkers to guide heart failure management
Kay-Won Chang1,2, Sutton Fox1,2, Sean Mojaver1,2
1a Division of Cardiology, Department of Medicine , University of California , San Diego , CA , USA.
Insights
Biomarkers like natriuretic peptides, troponin, and ST2 aid heart failure (HF) diagnosis. However, current evidence is mixed on their effectiveness in guiding HF management, necessitating further research.
Area of Science:
- Cardiology
- Biomarker Research
- Heart Failure Management
Background:
- Biomarkers have transformed heart failure (HF) diagnosis.
- Optimal strategies for using biomarkers to guide HF management are not well-established.
Purpose of the Study:
- To review the current literature on utilizing biomarkers for guiding heart failure management.
- To assess the role of natriuretic peptides, troponin, and ST2 in HF management.
Main Methods:
- Conducted an exhaustive literature search for studies on biomarker-guided HF management.
- Scrutinized HF guidelines and utilized Medline for reference identification.
Main Results:
- Most trials focused on secondary prevention in chronic HF patients.
- Emerging data exists for primary HF prevention and acute HF therapy.
- Current data on biomarker-guided HF management is mixed.
Conclusions:
- Further research is required to optimize the use of biomarkers in improving heart failure management.
- Understanding how to best utilize specific biomarkers like natriuretic peptides, troponin, and ST2 is crucial.
Introduction:
Biomarkers have revolutionized the diagnosis of heart failure (HF), but it remains unclear how to use biomarkers to guide management of HF. Areas covered: An exhaustive literature search on using biomarkers to guide HF management was performed. HF guidelines were carefully scrutinized for references pertaining to this topic, and Medline was employed to identify further references. This review focused on natriuretic peptides, troponin, and ST2 as biomarkers used to guide HF management. Most trials have examined secondary prevention of chronic HF patients, and data on primary prevention of HF and therapy of acute HF are emerging. Expert commentary: While the current data on using biomarkers to guide HF management remain mixed, more research is necessary to better understand how to utilize biomarkers to improve HF management.
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