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Multistability in the corticothalamic system.

Paula Sanz-Leon1, P A Robinson1

  • 1School of Physics, University of Sydney, NSW 2006, Australia; Center for Integrative Brain Function, University of Sydney, NSW 2006, Australia.

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|August 24, 2017
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Summary
This summary is machine-generated.

Neural field theory reveals multiple brain states in adult humans during waking. The number of neural connections, not previously emphasized, determines brain state multiplicity, potentially explaining hyperarousal.

Keywords:
Hyperarousal statesMarginal stabilitySteady states

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Theoretical Neuroscience

Background:

  • The corticothalamic system is crucial for regulating arousal and consciousness.
  • Understanding the dynamic properties of neural networks, particularly steady states and their stability, is essential for comprehending brain function during wakefulness.

Purpose of the Study:

  • To analyze the steady-state solutions and linear stability of the corticothalamic system within physiological parameter ranges for human waking states.
  • To explore the impact of synaptic couplings on the system's multistability.

Main Methods:

  • Utilized neural field theory to model the corticothalamic system.
  • Investigated an eight-dimensional parameter space defined by synaptic couplings.
  • Systematically identified multistable regions and analyzed steady-state solutions and their linear stability.

Main Results:

  • Confirmed the existence of up to five steady-state solutions, with up to three being linearly stable.
  • Identified the number of nonzero connections as a key determinant for high multiplicities of multistability.
  • Found that multistability occurs with an inhibitory intracortical loop and the presence of the intrathalamic loop.

Conclusions:

  • The number of nonzero connections is a novel determinant of multistability in mesoscopic brain models.
  • Additional steady states, characterized by increased thalamic activity, may represent hyperarousal states.
  • Corticothalamic projections failing to attenuate cortical activity could lead to these hyperarousal states.