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Targeting vasa vasorum dysfunction to prevent atherosclerosis.

Erin C Boyle1, Daniel G Sedding2, Axel Haverich3

  • 1Department of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.

Vascular Pharmacology
|August 24, 2017
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Summary
This summary is machine-generated.

Vasa vasorum, the small blood vessels supplying large arteries, are implicated in atherosclerosis development. Targeting their cellular metabolism and epigenetics may offer new prevention strategies for this vascular disease.

Keywords:
AtherosclerosisEndothelial metabolismEpigenetic regulationNeoangiogenesisVasa vasorummicroRNA

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Area of Science:

  • Cardiovascular Biology
  • Vascular Medicine
  • Atherosclerosis Research

Background:

  • Vasa vasorum are microvessels supplying nutrients and oxygen to large blood vessels.
  • Emerging evidence highlights the critical role of vasa vasorum in atherosclerosis pathogenesis.
  • Microvascular dysfunction is increasingly recognized as a key factor in initiating cardiovascular disease.

Purpose of the Study:

  • To review the role of microvascular dysfunction in the initiation of atherosclerosis.
  • To explore novel therapeutic strategies targeting vasa vasorum for disease prevention.
  • To discuss harnessing cellular metabolism and epigenetic modifications in vasa vasorum for atheroprotection.

Main Methods:

  • Literature review focusing on vasa vasorum and atherosclerosis.
  • Analysis of current understanding of microvascular dysfunction in large vessel walls.
  • Exploration of potential therapeutic targets within vasa vasorum endothelial cells.

Main Results:

  • Vasa vasorum dysfunction contributes significantly to the initiation of atherosclerosis.
  • Targeting vasa vasorum offers promising avenues for preventative therapies.
  • Modulating cellular metabolism and epigenetics of vasa vasorum neovessels is a potential strategy.

Conclusions:

  • Microvascular dysfunction of vasa vasorum is a critical factor in atherosclerosis initiation.
  • Therapeutic interventions targeting vasa vasorum metabolism and epigenetics may prevent disease.
  • Understanding vasa vasorum biology opens new frontiers in cardiovascular disease prevention.