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Bystander signaling via oxidative metabolism
Humaira Aziz Sawal1, Kashif Asghar2, Matthias Bureik3
1Healthcare Biotechnology Department, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad.
Oncotargets and Therapy
|August 24, 2017
Summary
The radiation-induced bystander effect (RIBE) involves non-irradiated cells experiencing biological damage. Reactive oxygen species (ROS) act as key signaling molecules mediating these bystander effects.
Area of Science:
- Cell biology
- Radiation biology
- Oxidative stress
Background:
- The radiation-induced bystander effect (RIBE) describes biological responses in cells not directly hit by radiation.
- RIBE contributes to DNA damage, tumorigenesis, apoptosis, and inflammation via oxidative stress.
- Cellular communication, through gap junctions or secreted factors, mediates RIBE.
Purpose of the Study:
- To review the role of reactive oxygen species (ROS) as mediators of the radiation-induced bystander effect.
- To outline the sources of ROS involved in cellular bystander responses.
- To provide methods for investigating ROS-mediated RIBE.
Main Methods:
- Literature review focusing on reactive oxygen species (ROS) and the radiation-induced bystander effect (RIBE).
- Analysis of signaling pathways involving ROS in cellular communication.
- Discussion of experimental approaches for studying ROS in RIBE.
Main Results:
- Reactive oxygen species (ROS) are identified as crucial signaling molecules in RIBE.
- ROS can be produced endogenously or secreted, influencing bystander cells.
- Despite short half-lives, ROS exert cumulative effects, triggering inflammation, apoptosis, and potentially tumorigenesis.
Conclusions:
- Reactive oxygen species (ROS) play a significant role in mediating the radiation-induced bystander effect.
- Understanding ROS signaling is critical for comprehending RIBE's impact on cellular health.
- Further research into ROS-mediated bystander effects is warranted for radiation biology and cancer research.
Keywords:
bystander signalingoxidative stressradiation-induced bystander effect (RIBE)reactive oxygen species (ROS)tumorigenesisMore Related Videos
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