Related Experiment Videos
Serum immunoreactive beta-endorphin in the human ovulatory cycle
International Journal of Fertility
|March 1, 1987
Summary
Serum immunoreactive beta-endorphin (IR-beta-EP) levels fluctuate throughout the ovulatory cycle in women. These changes, particularly higher levels in the luteal phase, suggest influence from ovarian sex steroids on beta-endorphin regulation.
Area of Science:
- Reproductive Endocrinology
- Neuroendocrinology
Background:
- Endogenous opioids, such as beta-endorphin, play roles in physiological regulation.
- Hormonal fluctuations during the menstrual cycle influence various bodily functions.
Purpose of the Study:
- To investigate the daily fluctuations of serum immunoreactive beta-endorphin (IR-beta-EP) during the ovulatory cycle.
- To explore the relationship between IR-beta-EP levels and key reproductive hormones.
Main Methods:
- Daily serum levels of IR-beta-EP, LH, FSH, 17 beta-oestradiol, progesterone, and prolactin were measured in five healthy Chinese women.
- Data were standardized using Z scores for composite cycle analysis.
Main Results:
- Serum IR-beta-EP levels exhibited significant fluctuations across follicular, luteal, and menstrual phases.
- A preovulatory rise in IR-beta-EP preceded the LH surge, followed by a postovulatory dip.
- The highest IR-beta-EP concentrations were observed during the late luteal phase.
Conclusions:
- Endogenous beta-EP fluctuations during the menstrual cycle are influenced by ovarian sex steroids.
- Beta-endorphin may play a role in regulating gonadotropin release during normal ovulatory cycles.