Related Experiment Video

Updated: Feb 24, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

6.0K

A counseling program on nuisance bleeding improves quality of life in patients on dual antiplatelet therapy: A

Simone Biscaglia1, Elisabetta Tonet1, Rita Pavasini1

  • 1Cardiovascular Section, Medical Sciences Department, Azienda Ospedaliera Universitaria S.Anna, Ferrara, Italy.

Plos One
|August 24, 2017
PubMed

Insights

A new counseling program significantly improved quality of life for patients on dual antiplatelet therapy (DAPT) by reducing nuisance bleeding concerns. This intervention also lowered drug discontinuation rates, enhancing patient outcomes.

Area of Science:

  • Cardiology
  • Clinical Trials
  • Patient Quality of Life

Background:

  • Nuisance bleeding significantly impacts quality of life and adherence in patients on dual antiplatelet therapy (DAPT).
  • Previous randomized trials have not specifically evaluated the effect of nuisance bleeding on quality of life.

Purpose of the Study:

  • To assess the impact of a multimodal counseling program on quality of life in patients undergoing DAPT.
  • To evaluate the effect of this intervention on DAPT withdrawal rates and patient-reported outcomes.

Main Methods:

  • The BATMAN trial randomized 448 patients to either a multimodal counseling program or usual care.
  • Quality of life was measured using the EuroQol-5 Dimension (EQ-5D) visual analog scale (VAS) at 1 and 6 months.
  • Secondary endpoints included DAPT withdrawal, information seeking, and adverse events.

Main Results:

  • Patients receiving the counseling program showed significantly higher EQ-5D VAS scores at 1 and 6 months compared to the control group.
  • The intervention group reported less pain/discomfort and anxiety/depression.
  • DAPT withdrawal rates were significantly lower in the intervention arm (0.4% vs. 3%).

Conclusions:

  • A systematic multimodal counseling program effectively improves quality of life for patients on DAPT.
  • This intervention also reduces the rate of DAPT discontinuation, suggesting improved patient management and adherence.
Abstract

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.4K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
403
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
324
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
288
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
545
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
399