Colchicine: an ancient drug with novel applications
B Dasgeb1,2, D Kornreich1, K McGuinn1
1Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, U.S.A.
The British Journal of Dermatology
|August 24, 2017
Summary
Colchicine, a gout treatment used for over 1000 years, is now showing new potential in oncology, immunology, cardiology, and dermatology. Research is exploring its effectiveness in treating various inflammatory and autoimmune skin conditions.
Area of Science:
- Pharmacology
- Dermatology
- Immunology
Background:
- Colchicine has a long history of use, primarily for gout and familial Mediterranean fever.
- Its 2009 FDA approval spurred further research into its therapeutic applications.
- Familial Mediterranean fever is a genetic autoinflammatory disorder.
Observation:
- Recent studies reveal colchicine's efficacy in diverse medical fields beyond its traditional uses.
- Large patient cohorts using colchicine for gout have been instrumental in these discoveries.
- Emerging research highlights its role in managing complex dermatological conditions.
Findings:
- Colchicine demonstrates novel applications in oncology, immunology, and cardiology.
- In dermatology, colchicine is being investigated for treating epidermolysis bullosa acquisita, leucocytoclastic vasculitis, and aphthous stomatitis.
- These findings expand the therapeutic landscape for this ancient compound.
Implications:
- The re-evaluation of colchicine opens new avenues for treating various diseases.
- Further research may solidify colchicine's position as a versatile therapeutic agent.
- This underscores the importance of continued investigation into established medications for novel uses.
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