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Updated: Feb 24, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilia secondary to lenalidomide therapy
V Escudero-Vilaplana1,2, S Osorio-Prendes2,3, R Collado-Borrell1,2
1Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
What Is Known And Objective:
Limited data are available on eosinophilia as a drug adverse event. We describe a case of eosinophilia from lenalidomide therapy.
Case Description:
A 50-year-old woman received lenalidomide, dexamethasone and cyclophosphamide as POEMS syndrome treatment. Eosinophil count rose during lenalidomide treatment and decreased in the periods off treatment. Naranjo nomogram suggested a probable association between the use of lenalidomide and eosinophilia.
What Is New And Conclusion:
Eosinophilia has rarely been described with lenalidomide. This case shows a clear temporal relationship between lenalidomide and eosinophilia.
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