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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilia secondary to lenalidomide therapy.
V Escudero-Vilaplana1,2, S Osorio-Prendes2,3, R Collado-Borrell1,2
1Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Journal of Clinical Pharmacy and Therapeutics
|August 24, 2017
Summary
Lenalidomide therapy can cause eosinophilia, a rare drug adverse event. This case highlights a clear temporal link between lenalidomide use and increased eosinophil counts in a POEMS syndrome patient.
Area of Science:
- Hematology
- Pharmacology
- Oncology
Background:
- Eosinophilia as a drug adverse event is infrequently documented.
- Lenalidomide is an immunomodulatory drug used in treating various hematological malignancies and POEMS syndrome.
Observation:
- A 50-year-old female patient with POEMS syndrome was treated with lenalidomide, dexamethasone, and cyclophosphamide.
- Eosinophil counts elevated during lenalidomide treatment cycles.
- Eosinophil counts decreased when lenalidomide was discontinued.
Findings:
- The Naranjo nomogram indicated a probable association between lenalidomide and the observed eosinophilia.
- This case presents a rare instance of eosinophilia linked to lenalidomide therapy.
- A distinct temporal relationship was established between lenalidomide administration and eosinophilia.
Implications:
- Clinicians should consider eosinophilia as a potential adverse effect of lenalidomide.
- Monitoring eosinophil counts may be warranted in patients receiving lenalidomide.
- Further research is needed to elucidate the mechanisms underlying lenalidomide-induced eosinophilia.
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