Hydrogels Based on Ag⁺ -Modulated Assembly of 5'-Adenosine Monophosphate for Enriching Biomolecules

Supramolecular hydrogels obtained by combining 5'-adenosine monophosphate (AMP) with Ag⁺ were fabricated in this work. Their gelation capability was enhanced by increasing the concentration of Ag⁺ or decreasing the pH. The gels are very sensitive to light, which endows them with potential applications as visible-light photosensitive materials. Coordination between the nucleobase of AMP and Ag⁺ , as well as π-π stacking of nucleobases, are considered to be the main driving forces for self-assembly. The hydrogels successfully achieved the encapsulation and enrichment of biomolecules. Hydrogen bonding between the amino group of guest molecules and silver nanoparticles along the nanofibers drives the enrichment and is considered to be a crucial interaction.