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TRPM5 in the battle against diabetes and obesity

R Vennekens1,2, M Mesuere1,2, K Philippaert1,2

  • 1VIB Center for Brain & Disease Research, Leuven, Belgium.

Acta Physiologica (Oxford, England)
|August 24, 2017
PubMed

Insights

Transient Receptor Potential Melastatin 5 (TRPM5) channels regulate taste perception and insulin secretion. Knockout mice lacking TRPM5 exhibit impaired taste and reduced glucose-induced insulin release, highlighting its physiological importance.

Area of Science:

  • Physiology
  • Molecular Biology
  • Cell Biology

Background:

  • TRPM5 is a non-selective monovalent cation channel.
  • It is activated by intracellular calcium (Ca2+).
  • TRPM5 is expressed in taste receptor cells and pancreatic beta-cells.

Purpose of the Study:

  • To review the activation, selectivity, modulation, and physiological roles of TRPM5.
  • To summarize findings from TRPM5 knockout mouse models.

Main Methods:

  • Investigation using Trpm5 knockout mouse models.
  • Analysis of taste perception in knockout mice.
  • Assessment of glucose-induced insulin secretion in knockout mice.

Main Results:

  • Trpm5-/- mice lack type II taste perception.
  • Reduced glucose-induced insulin secretion was observed in Trpm5-/- mice.
  • Reduced TRPM5 expression is linked to obesity and metabolic syndrome.

Conclusions:

  • TRPM5 plays a critical role in taste perception and insulin secretion.
  • Dysfunction of TRPM5 is associated with type II diabetes and metabolic syndrome.
  • Further research into TRPM5 modulation could offer therapeutic strategies.
Keywords:
TRPM5diabetesion channelobesitytastetransient receptor potential channel

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