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Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations

Jie Chen1, Lixin Li1, Yunfei An1

  • 1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Journal of Clinical Laboratory Analysis
|August 24, 2017
PubMed

Insights

Certain genetic variants, specifically the T allele of signal transducer and activator of transcription 4 (STAT4) and the A allele of IL-18, are linked to an increased risk of posttransplantation diabetes mellitus (PTDM). These findings may offer new markers for PTDM prediction.

Area of Science:

  • Genetics
  • Immunology
  • Transplantation Medicine

Background:

  • Posttransplantation diabetes mellitus (PTDM) is a significant complication following solid organ transplantation.
  • Identifying genetic factors associated with PTDM risk is crucial for patient management.

Purpose of the Study:

  • To investigate the association between nine specific genetic variants and the development of PTDM in Chinese Han liver transplant recipients.
  • To explore the relationship between these genetic variants and inflammatory cytokine levels.

Main Methods:

  • Genotyping of nine genetic variants including HLA-DP, HLA-DQ, STAT4, IL-28B, and IL-18 in 260 liver transplant recipients using high-resolution melting curve analysis.
  • Quantification of serum inflammatory markers (IL-1β, IL-6, IL-17, IFN-γ, etc.) using Bio-Plex suspension array system.

Main Results:

  • The T allele of signal transducer and activator of transcription 4 (STAT4) (rs7574865) and the A allele of IL-18 (rs1946518) were found to increase the risk of insulin resistance and PTDM.
  • Recipients with the STAT4 (rs7574865) T allele showed elevated levels of IL-1β, interferon-γ, monocyte chemoattractant protein, and macrophage inflammatory protein-1b.

Conclusions:

  • The genetic variants STAT4 (rs7574865) and IL-18 (rs1946518) may serve as important predictive markers for PTDM.
  • These genetic factors are associated with altered inflammatory profiles in transplant recipients.
Abstract

Keywords:
PTDMHLA-DPHLA-DQIL-18IL-28BSTAT4

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