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EMT: Mechanisms and therapeutic implications.

Mohini Singh1, Nicolas Yelle1, Chitra Venugopal2

  • 1McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.

Pharmacology & Therapeutics
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Summary
This summary is machine-generated.

The epithelial-mesenchymal transition (EMT) drives cancer metastasis and therapy resistance. Targeting EMT could prevent tumor spread and eradicate existing metastatic cells.

Keywords:
CSCCTCEMTEpithelial-mesenchymal transitionMCSCsMETMetastasis

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Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Metastasis, the spread of cancer cells, is a primary cause of cancer-related deaths.
  • Epithelial-mesenchymal transition (EMT) is a developmental process implicated in cancer progression and metastasis.
  • EMT is crucial for metastatic cancer stem cells (MCSCs), enhancing dissemination and therapy resistance.

Purpose of the Study:

  • To review the mechanisms of EMT in cancer metastasis.
  • To summarize current therapeutic strategies targeting EMT.
  • To highlight EMT's role in cancer progression and treatment resistance.

Main Methods:

  • Review of existing literature on EMT in cancer.
  • Analysis of molecular mechanisms driving EMT.
  • Summary of clinical trials targeting EMT pathways.

Main Results:

  • EMT facilitates cancer cell dissemination and the development of metastatic colonies.
  • EMT is associated with increased resistance to cancer therapies.
  • Targeting EMT pathways shows promise in preclinical and clinical settings.

Conclusions:

  • EMT is a critical driver of cancer metastasis and therapeutic resistance.
  • Targeting EMT offers a promising strategy for preventing cancer spread and treating advanced-stage disease.
  • Further research into EMT mechanisms and targeted therapies is warranted.