Jove
Visualize
Contact Us

Related Experiment Videos

Doxycycline prophylaxis for falciparum malaria.

L W Pang, N Limsomwong, E F Boudreau

    Lancet (London, England)
    |May 23, 1987
    PubMed
    Summary

    Doxycycline significantly outperformed chloroquine in preventing falciparum malaria infections in schoolchildren. This malaria prevention study found doxycycline to be more effective with comparable side-effect rates.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Cyclic Cushing syndrome related to ectopic ACTH syndrome: a case report].

    Zhonghua nei ke za zhi·2021
    Same author

    Thymic expression of the main immunogenic region of titin in thymomatous myasthenia gravis.

    The Journal of international medical research·2010
    Same author

    Attempts at virus recovery from patients dying of Thai haemorrhagic fever.

    Bulletin of the World Health Organization·2010
    Same author

    Recovery of dengue and chikungunya viruses from Thai haemorrhagic fever patients by passage in sucking mice.

    Bulletin of the World Health Organization·2010
    Same author

    Recovery of dengue and other viruses in mice and tissue culture from Thai mosquitos.

    Bulletin of the World Health Organization·2010
    Same author

    Evaluation of suckling mice and tissue culture for recovery of viruses from haemorrhagic fever patients in Thailand.

    Bulletin of the World Health Organization·2010
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Tropical medicine
    • Infectious disease epidemiology
    • Pharmacology

    Background:

    • Malaria remains a significant health concern in endemic regions.
    • Chloroquine resistance in Plasmodium falciparum necessitates alternative prophylactic strategies.
    • School-aged children in endemic areas are particularly vulnerable to malaria.

    Purpose of the Study:

    • To compare the efficacy of doxycycline versus chloroquine for malaria prevention.
    • To evaluate the safety profile of doxycycline compared to chloroquine in children.

    Main Methods:

    • A randomized controlled trial involving 188 schoolchildren aged 10-15 in a malaria-endemic area.
    • Participants were assigned to receive daily doxycycline or weekly chloroquine.
    • Weekly blood smears and monitoring for side-effects were conducted.

    Main Results:

    • Doxycycline prophylaxis resulted in significantly fewer Plasmodium falciparum infections (5 cases) compared to chloroquine (31 cases).
    • The difference in efficacy was statistically significant (p < 0.0001).
    • No significant increase in adverse events was observed in the doxycycline group.

    Conclusions:

    • Doxycycline is a highly effective chemoprophylactic agent against falciparum malaria in children.
    • Doxycycline offers a superior alternative to chloroquine for malaria prevention in this population.
    • The safety profile of doxycycline was comparable to chloroquine, supporting its use.

    Related Experiment Videos